Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat.

نویسندگان

  • K M Koley
  • J Lal
چکیده

Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.

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عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 38 3  شماره 

صفحات  -

تاریخ انتشار 1994